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Innovative solutions for advanced vascular care and health

Who We Are Science & Innovation

For Alfasigma, being able to help people living with vascular diseases means understanding, and truly caring about, their needs

Nearly 80 years of experience means we have a deep knowledge of the daily impact of vascular conditions on patients and their caregivers. Enhancing quality of life and preventing serious complications are always foremost to mind.

1/5 Vascular health

What conditions does vascular health cover?

Vascular diseases include a broad spectrum of conditions that affect blood flow in arteries and veins, and microcirculation, often with significant consequences for patients’ quality of life. While vascular disorders can present in many forms, their impact is frequently progressive and underestimated, especially in the early stages.

2/5 Vascular health

Vascular diseases are a diverse group of conditions that affect the body’s network of blood vessels (arteries, veins and capillaries) and disrupt healthy blood flow.[1] Common vascular conditions include:

  • chronic venous disease
  • peripheral artery disease
  • deep vein thrombosis
  • diabetic angiopathies.[2]

3/5 Vascular health

Chronic venous disease can cause visible changes, such as spider veins, venous ulcers and edemas, as well as non-visible symptoms such as fatigue, cramps, and itching or painful skin.[3] These symptoms can significantly reduce quality of life — from limiting mobility to disturbing sleep and daily activities.[4]

4/5 Vascular health

Non-visible signs often have the greater impact on quality of life in the early stages, while visible signs tend to become the primary concern as the disease progresses.[5] For chronic venous disease in particular, early diagnosis and intervention are essential to prevent progression of the disease.[6] However, many patients remain undiagnosed in the early stages, missing the opportunity for timely treatment and better long-term outcomes.[7]

5/5 Vascular health

Risk factors for chronic venous disease development include genetic predisposition, women, pregnancy, increasing age, prolonged standing, obesity, and smoking.

Endothelial dysfunction plays a key role in the pathogenesis of CVD, as glycocalyx disruption and endothelial impairment contribute to disease initiation and progression.[7a]

Products

Alfasigma’s portfolio is diverse, ranging from over-the-counter solutions to prescription medicines designed to meet a wide spectrum of health needs

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Chronic venous disease: key facts and figures

Chronic venous disease

affects an estimated 45% of the population, ranking it as one of the most prevalent health conditions, alongside obesity and diabetes [8]

People with chronic venous disease

have an increased cardiovascular risk, including a significantly higher risk of developing venous thromboembolism (blood clots in the veins), a condition that affects approximately 10 million people worldwide [9]

1 in 3 people

with chronic venous disease isolate themselves and avoid social activities as a result of their condition [10]

Only 30% of people diagnosed

with early chronic venous disease use oral or topical treatments to manage their condition [11]

This is how we do it: we call it “the science of ingenuity”

We have a long-term commitment to understanding real needs and creating solutions grounded in scientific expertise and human insight. It is about clarity, care and innovation designed to make a real change in people’s lives.

Our Strategy
  • [1] Cleveland Clinc. Vascular Disease (Vasculopathy). 2022. Available from: https://my.clevelandclinic.org/health/diseases/17604-vascular-disease
  • [2] Cleveland Clinc. Vascular Disease (Vasculopathy). 2022. Available from: https://my.clevelandclinic.org/health/diseases/17604-vascular-disease; Gibbons GW, Shaw PM. Diabetic vascular disease: characteristics of vascular disease unique to the diabetic patient. Semin Vasc Surg. 2012;25(2):89-92. doi:10.1053/j.semvascsurg.2012.04.005.
  • [3] Cleveland Clinc. Vascular Disease (Vasculopathy). 2022. Available from: https://my.clevelandclinic.org/health/diseases/17604-vascular-disease; De Maeseneer MG et al. Editor's Choice - European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs. Eur J Vasc Endovasc Surg. 2022;63(2):184-267. doi:10.1016/j.ejvs.2021.12.024.
  • [4] De Maeseneer MG et al. Editor's Choice - European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs. Eur J Vasc Endovasc Surg. 2022;63(2):184-267. doi:10.1016/j.ejvs.2021.12.024.
  • [5] Alfasigma. CVD Preliminary Mapping Phase Report. 2024. Data on File.
  • [6] Jarošíková R, Roztočil K, Husáková J, et al. Chronic Venous Disease and Its Intersections With Diabetes Mellitus. Physiol Res. 2023;72(3):280-286. doi:10.33549/physiolres.935033.
  • [7] Feodor T, Baila S, Mitea IA, Branisteanu DE, Vittos O. Epidemiology and clinical characteristics of chronic venous disease in Romania. Exp Ther Med. 2019;17(2):1097-1105. doi:10.3892/etm.2018.7059
  • [7a] Diaz JA et al., Int Angiol 2024;43:563–590
  • [8] Alfasigma. CVD Preliminary Mapping Phase Report. 2024. Data on File; Jarošíková R, Roztočil K, Husáková J, et al. Chronic Venous Disease and Its Intersections With Diabetes Mellitus. Physiol Res. 2023;72(3):280-286. doi:10.33549/physiolres.935033.
  • [9] Musil D, Kaletová M, Herman J. Venous thromboembolism - prevalence and risk factors in chronic venous disease patients. Phlebology. 2017;32(2):135-140. doi:10.1177/0268355516633392; Brækkan, S. K. & Hansen, J. (2023) VTE epidemiology and challenges for VTE prevention at the population level. Thrombosis Update. 10 100132. 10.1016/j.tru.2023.100132.
  • [10] Gibbons GW, Shaw PM. Diabetic vascular disease: characteristics of vascular disease unique to the diabetic patient. Semin Vasc Surg. 2012;25(2):89-92. doi:10.1053/j.semvascsurg.2012.04.005.
  • [11] Gibbons GW, Shaw PM. Diabetic vascular disease: characteristics of vascular disease unique to the diabetic patient. Semin Vasc Surg. 2012;25(2):89-92. doi:10.1053/j.semvascsurg.2012.04.005; Feodor T, Baila S, Mitea IA, Branisteanu DE, Vittos O. Epidemiology and clinical characteristics of chronic venous disease in Romania. Exp Ther Med. 2019;17(2):1097-1105. doi:10.3892/etm.2018.7059