Our Company / Alfasigma at glance

with passion

Alfasigma is one of the top 5 pharmaceutical companies in Italy, with a turnover in 2022 exceeding 1.2 billion euro. It’s a private company with more than 75% owned by the family of the founder. The Alfasigma legacy is firmly anchored in a long lasting heritage of innovation and success, beginning in 1948 in Bologna (Italy) thanks to Marino Golinelli, entrepreneur and philanthropist, who recently passed away at the age of 101.

From the beginning Alfasigma has always pursued a twofold strategy:
– internally, a strong focus on Research & Development and Manufacturing around some proprietary
molecules, some of which represent more than 50% of the sales;
– externally, developing a robust strategy of mergers and acquisitions of other Italian and international companies (Sigma Tau, Pamlabs, Sofar).

Currently Alfasigma has around 4.000 employees.

With an extensive presence in the international market, Alfasigma can count on a large number of direct subsidiaries in 24 countries, 2 Research & Development centers, 6 manufacturing plants, as well as on a network of top-level distributors which guarantee its products distribution on five continents and in more than 100 countries.

Alfasigma, leader in the gastrointestinal area, has a portfolio that ranges from prescription specialties to self-medication products, up to nutraceuticals.

Geographic coverage



> 100 countries


24 countries


€ 1.212

millions in 2022


5 proprietary molecules
Rifaximin, Sulodexide, Carnitine, L-Methylfolate, Parnaparin

Contract Manufacturing – Business Unit

Alongside its traditional business, the company is also playing a leading role supplying to other multinational and Italian pharmaceutical companies thanks to its Contract Manufacturing division, which has been on a constant growth trajectory since 2017 with a CAGR (Compound Annual Growth Rate) of 10.2%.


R&D centers


Manufacturing plants


Subsidiaries worldwide

Read More

Alfasigma was established in 2015 from the merging of two big companies – Alfa Wassermann and Sigma-Tau – both with over 60 years of history behind them.
In 2019 Alfasigma adopted a new Leadership Model that prescribes five preferred behaviors to be put into practice daily.
Social contract between the company and internal and external stakeholders having a normative value for the entire Alfasigma system.

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